Mecamylamine Hydrochloride
Mecamylamine Hydrochloride is listed in the FDA National Drug Code directory with 3 NDC codes, marketed under brand name including Vecamyl. Available dosage forms: tablet, powder.
Drug Details
- Generic Name
- Mecamylamine Hydrochloride
- Brand Names
- Vecamyl
- Application Number
- ANDA204054
- Sponsor
- TILDE Sciences LLC
- NDC Codes
- 3
- Dosage Forms
- TABLET, POWDER
- Routes
- ORAL
- Active Ingredients
- MECAMYLAMINE HYDROCHLORIDE
Indications and Usage
INDICATIONS AND USAGE For the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension.
Warnings
WARNINGS Mecamylamine, a secondary amine, readily penetrates into the brain and thus may produce central nervous system effects. Tremor, choreiform movements, mental aberrations, and convulsions may occur rarely. These have occurred most often when large doses of Mecamylamine HCl were used, especially in patients with cerebral or renal insufficiency. When ganglion blockers or other potent antihypertensive drugs are discontinued suddenly, hypertensive levels return. In patients with malignant hypertension and others, this may occur abruptly and may cause fatal cerebral vascular accidents or acute congestive heart failure. When Mecamylamine HCl is withdrawn, this should be done gradually and other antihypertensive therapy usually must be substituted. On the other hand, the effects of Mecamylamine HCl sometimes may last from hours to days after therapy is discontinued.