Siltuximab
Drug Details
- Generic Name
- Siltuximab
- Brand Names
- Sylvant
- Application Number
- BLA125496
- Sponsor
- Recordati Rare Diseases, Inc.
- NDC Codes
- 2
- Dosage Forms
- INJECTION, POWDER, FOR SOLUTION
- Routes
- INTRAVENOUS
- Active Ingredients
- SILTUXIMAB
Indications and Usage
1 INDICATIONS AND USAGE SYLVANT is indicated for the treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative. SYLVANT is an interleukin-6 (IL-6) antagonist indicated for the treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative. ( 1 ) Limitations of Use SYLVANT was not studied in patients with MCD who are HIV positive or HHV-8 positive because SYLVANT did not bind to virally produced IL-6 in a nonclinical study. Limitations of Use SYLVANT was not studied in patients with MCD who are HIV positive or HHV-8 positive because SYLVANT did not bind to virally produced IL-6 in a nonclinical study.