554855

Nesher Pharmaceuticals (USA) LLC — FEI 1937079

Inspection Details

Classification
Official Action Indicated (OAI) (OAI)
End Date
February 2, 2009
Fiscal Year
2009
Product Type
Drugs
Project Area
Drug Quality Assurance
Location
Saint Louis, MO (United States)

Citations

IDCFRDescription
110521 CFR 211.22(d)Procedures not in writing, fully followed
121321 CFR 211.67(a)Cleaning / Sanitizing / Maintenance
121521 CFR 211.67(b)Written procedures not established/followed
122021 CFR 211.67(b)(3)Cleaning SOPs/instructions
122721 CFR 211.67(c)Cleaning/maintenance records not kept
127421 CFR 211.68(a)Calibration/Inspection/Checking not done
135821 CFR 211.100(b)SOPs not followed / documented
163321 CFR 211.130(d)Examination of packaging and labeling
163621 CFR 211.130(e)Packaging line inspection before use
172621 CFR 211.86Rotation of components/containers/closures
180921 CFR 211.160(a)Following/documenting laboratory controls
192221 CFR 211.166(a)(4)Testing in same container - closure system
197521 CFR 211.182Written records kept in individual logs
202621 CFR 211.192Quality control unit review of records
202721 CFR 211.192Investigations of discrepancies, failures
202821 CFR 211.192Extent of discrepancy, failure investigations
203221 CFR 211.194(b)Test method modification records not maintained
203421 CFR 211.194(d)Laboratory equipment calibration records
239921 CFR 211.194(a)(2)Laboratory Test Method Verification
240121 CFR 211.194(a)(4)Complete Test Data
356921 CFR 211.89Quarantine of Rejected Components et. al.
357121 CFR 211.100(a)Changes to Procedures Not Reviewed, Approved
358221 CFR 211.105(a)Identification of containers, lines, equipment
358521 CFR 211.110(a)Control procedures to monitor and validate performance
360321 CFR 211.160(b)Scientifically sound laboratory controls
431421 CFR 211.84(d)(2)Reports of Analysis (Components)
436921 CFR 211.188(b)(11)Identification of persons involved, each significant step
438921 CFR 211.198(a)Procedures to be written and followed
440221 CFR 211.192Written record of investigation incomplete
441321 CFR 211.194(a)(8)Second person sign off
441521 CFR 211.204Returned drug products with doubt cast as to safety et. al.
441821 CFR 211.42(b)Adequate space lacking to prevent mix-ups and contamination
457621 CFR 211.192No written record of investigation
891121 CFR 314.81(b)(1)(ii)Failure to meet specifications
891421 CFR 314.81(b)(2)(iv)(b)Mfg and control changes not requiring a supplemental app.