atovaquone and proguanil hydrochloride

FDA Drug Profile — MALARONE, Atovaquone and Proguanil Hydrochloride, Atovaquone and Proguanil HCl

atovaquone and proguanil hydrochloride is listed in the FDA National Drug Code directory with 11 NDC codes, marketed under brand names including MALARONE, Atovaquone and Proguanil Hydrochloride, Atovaquone and Proguanil HCl. Available dosage form: tablet, film coated.

Drug Details

Generic Name
atovaquone and proguanil hydrochloride
Brand Names
MALARONE, Atovaquone and Proguanil Hydrochloride, Atovaquone and Proguanil HCl
Application Number
NDA021078
Sponsor
GlaxoSmithKline LLC
NDC Codes
11
Dosage Forms
TABLET, FILM COATED
Routes
ORAL
Active Ingredients
ATOVAQUONE, PROGUANIL HYDROCHLORIDE

Indications and Usage

1 INDICATIONS AND USAGE Atovaquone and proguanil hydrochloride tablets are an antimalarial indicated for: • prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. ( 1.1 ) • treatment of acute, uncomplicated P. falciparum malaria. ( 1.2 ) 1.1 Prevention of Malaria Atovaquone and proguanil hydrochloride tablets are indicated for the prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. 1.2 Treatment of Malaria Atovaquone and proguanil hydrochloride tablets are indicated for the treatment of acute, uncomplicated P. falciparum malaria. Atovaquone and proguanil hydrochloride tablets have been shown to be effective in regions where the drugs chloroquine, halofantrine, mefloquine, and amodiaquine may have unacceptable failure rates, presumably due to drug resistance.